This session explores the growing role of HyFlex learning in P–12 education through the lens of special education and inclusive instructional design. Drawing on current research and practical examples, presenters will discuss how HyFlex models create opportunities for greater learner choice, flexibility, and engagement while addressing barriers that students with disabilities often experience. The presentation will examine how HyFlex environments can reduce sensory overload, support self-paced learning, increase educational continuity for students with health or attendance challenges, and foster greater autonomy. Particular attention will be paid to the relationship between HyFlex and Universal Design for Learning, demonstrating how multiple means of engagement, representation, and expression can be embedded into instructional design from the outset. Participants will also consider implementation challenges, including educator preparation, equitable access to technology, staffing considerations, and the need for systemic support structures. Through discussion and reflection, attendees will explore how designing for students at the margins can ultimately improve learning experiences for all students.